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, carbatrol may be superior to tegretol xr; the manufacturer emphasizes smoother blood levels over time less peaks and troughs .
Information about Tegretol.
CYP3A4 inducers can increase the rate of Tegretol metabolismDrugs that have been shownor that would be expectedto decrease plasma carbamazepine levels include cisplatindoxorubicin HClfelbamatefosphenytoinrifampinphenobarbitalphenytoinprimidonemethsuximidetheophyllineaminophylline.
There have been reports of associated paralysis and other symptoms of cerebral arterial insufficiencybut the exact relationship of these reactions to the drug has not been established.
Hyponatremia can occur as a result of treatment with TegretolIn many casesthe hyponatremia appears to be caused by the syndrome of inappropriate antidiuretic hormone secretionSIADHThe risk of developing SIADH with Tegretol treatment appears to be dose-relatedElderly patients and patients treated with diuretics are at greater risk of developing hyponatremiaConsider discontinuing Tegretol in patients with symptomatic hyponatremiaSigns and symptoms of hyponatremia include headachenew or increased seizure frequencydifficulty concentratingmemory impairmentconfusionweaknessand unsteadinesswhich can lead to fallsConsider discontinuing Tegretol in patients with symptomatic hyponatremia.
Therapy should be prescribed only after critical benefit-to-risk appraisal in patients with a history of cardiac conduction disturbanceincluding second-and third-degree AV heart blockcardiachepaticor renal damageadverse hematologic or hypersensitivity reaction to other drugsincluding reactions to other anticonvulsantsor interrupted courses of therapy with Tegretol.
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